Mechanobiology is the study of how physical forces, mechanical constraints, and motion affect cell activity in bodily fluids and tissues. These forces are transmitted to cells from either the surrounding fluid or the extracellular matrix, and they can have a profound impact on tissue growth, remodeling, damage, and disease. A point of major emphasis at Iowa is understanding the manner in which physical forces applied at the organ- and tissue-level propagate down to the cellular-level (i.e. multiscale mechanical interactions) and effect various signaling pathways that result in the conversion of mechanical signals into chemical signals (i.e. mechanotransduction), particularly with regard to cardiovascular and connective tissues, wound healing, tissue engineering, and cancer.