Wahle A, Gualano S, De A, Everett M, Olszewski ME, Vigmostad SC, Cinar S, Lee K, Sonka M, Lopez JJ:


Correlation of Peri-Procedural Cardiac Enzyme Release with Atherosclerotic Plaque Burden using 3-D Fusion of Intravascular Ultrasound and Angiography.

In:

Ünal G, Kakadiaris I, Slabaugh G, Tannenbaum A (eds):

The 1st International Workshop on Computer Vision for Intravascular and Intracardiac Imaging.

Samfundslitteratur, Frederiksberg

Page 90-97, 2006

More detailed description of the enyzme-release study, updating the abstract (Paper) (Poster) (Links)

Abstract: During the treatment of coronary atherosclerosis by percutaneous coronary interventions (PCI), cardiac enzymes indicating cell or muscle damage may be released and measured. Controversy exists regarding the importance of release of cardiac enzymes (i.e., the MB iso-enzyme of Creatine Kinase and Troponin) after coronary interventional procedures and the mechanism involved in this occurrence. While some have suggested that peri-procedural enzyme release or infarction may be a marker of atherosclerotic burden, others have shown its relationship to procedural complexity or plaque instability in unstable coronary syndromes. Using our previously developed and validated method for 3-D fusion of data from intravascular ultrasound (IVUS) and X-ray angiography, we investigated in 19 coronary vessel segments of 16 patients in-vivo whether peri-procedural cardiac enzyme release correlates with lesion or vessel atherosclerotic burden. Our results showed no evidence of a positive relationship, with consistent findings of a negative correlation between lesion and vessel atherosclerotic burden and the procedure-related release of cardiac enzymes. Except for a negative correlation between %-area stenosis and enzyme release (p<0.02), none of the correlations was statistically significant. We concluded that cardiac enzyme release during complex PCI is not a marker of atherosclerotic burden, supporting previous concepts relating these indices to procedure complexity and unstable plaques.