Kammermeyer Lecture Series

Thursday, March 6, 2014 - 3:30pm
101 Becker Communication Studies Building

  Nicholas A. Peppas, Sc.D. Fletcher Stuckey Pratt Chair in Engineering Professor of Biomedical Engineering, Chemical Engineering and Pharmacy Chairman, Biomedical Engineering Department Director of Center on Biomaterials, Drug Delivery, and Bionanotechnology The University of Texas at Austin Thursday, March 6, 2014Advances in Intelligent Hydrogels for Recognitive and Protein Delivery Systems ABSTRACT: Engineering the molecular design of intelligent hydrogels by controlling recognition and specificity is the first step in coordinating and duplicating complex biological and physiological processes. We address design and synthesis characteristics of nover crosslinked networks capable of protein release as well as artificial molecular structures capable of specific molecular recognition of biological molecules. Recent developments in protein delivery have been directed towards the preparation of targeted formulations for protein delivery to specific sites, use of environmentally–responsive polymers to achieve pH– or temperature–triggered delivery, usually in modulated mode, and improvement of the behavior of their mucoadhesive behavior and cell recognition.  Molecular imprinting and microimprinting techniques, which create stereo–specific three–dimensional binding cavities based on a biological compound of interest can lead to preparation of biomimetic materials for intelligent drug delivery, drug targeting, and tissue engineering. We have been successful in synthesizing novel glucose– and protein–binding polymers based on non–covalent directed interactions formed via molecular imprinting techniques within aqueous media. We have also used advanced modeling methods to identify preferred recognitive structures. BIOGRAPHY: Nicholas A. Peppas is the Fletcher Stuckey Pratt Chair in Engineering; Professor of Chemical Engineering, Biomedical Engineering and Pharmacy; Chairman of the Department of Biomedical Engineering, and Director of the Center for Biomaterials, Drug Delivery and Bionanotechnology of the University of Texas at Austin where he has been since January 2003. Previously, he was the Showalter Distinguished Professor of Biomedical Engineering at Purdue University. Peppas is internationally known for his pioneering research inbiomaterials, polymer physics, drug delivery, bionanotechnology and medical devices. He is particularly recognized for his pioneering work on polymer networks and hydrogels as biomaterials. He has provided the basic set of thermodynamic analysis of neutral and ionic networks in water and biological fluids and developed the basic equations of solute transport in hydrogels and networks.  His research blends modern molecular and cellular biology with engineering to generate the next–generation of medical systems and devices for patient treatment. Over the past 35 years he has set the fundamentals and rational design of drug delivery systems and developed models of drug and protein diffusion in controlled release devices and biological tissues. For example, using biomedical engineering principles and new biomedical transport theories, Peppas developed the equations that describe Fickian and non–Fickian diffusion in controlled release devices. The “Peppas equation” has become the standard method of analysis of diffusion through any pharmaceutical device. Using the modeling similarities of phase erosion and state erosion, he developed a unified model for all drug delivery systems. Similarly, he developed the theoretical framework for the analysis of transport through crosslinked biomaterials (the Peppas–Reinhart theory), ionic hydrogels (the Brannon–Peppas theory), and gel–tissue interactions via tethers (the Huang–Peppas theory and the Sahlin–Peppas equation).   His work has been translated to a number of commercial products from biomaterials for contact and intraocular lenses, to novel therapeutic protein delivery systems. He is the inventor of numerous medical products including contact and intraocular lenses, artificial kidney membranes, cartilage, devices for oral delivery of insulin for treatment of diabetics, calcitonin for osteoporosis and interferon beta for multiple sclerosis, and recognitive delivery systems with an estimated market of more $ 15 billion. For his contributions to chemical and biomedical engineering he received one of the highest national recognitions for engineering and technology, the 2012 Founders Award of the National Academy of Engineering (NAE). Peppas is an elected member of the National Academy of Engineering (NAE), theInstitute of Medicine of the National Academy, the National Academy of France, the Royal Academy of Spain, the Academy of Athens (Greece) and the Texas Academy of Medicine, Engineering and Sciences. In 2008, AIChE named him on of the One Hundred Chemical Engineers of the Modern Era. He has been recognized with 140 awards from the American Institute of Chemical Engineers (AIChE, Founders Award, William Walker Award, Institute Lecture, Jay Bailey Award, Food, Pharmaceuticals and Bioengineering Award, Materials Science and Engineering Award), the Biomedical Engineering Society (BMES, Distinguished Scientist Award), the American Institute of Medical and Biological Engineering (AIMBE, Pierre Galletti Award), the Society for Biomaterials (SFB, Founders, Clemson for Basic Research and William Hall Awards), the 2010 Acta Biomaterialia Gold Medal, the Controlled Release Society (CRS, Founders, Heller and Eurand Awards), the Association Pharmaceutique Galenique Industrielle (APGI, Maurice Janôt Award), the Distinguished Scientist of the Southern Universities Research Association, the American Society for Engineering Education (Benjamiin Carver Lamme, Dow ChE, General Electric, George Westinghouse, Curtis McGraw Awards) and other societies. He is President (2008–16) of the International Union of Societies of Biomaterials Science and Engineering (IUSBSE), Chair (2014–15) of the Engineering Section of the American Association for the Advancement of Science (AAAS), and a member of the SFB Board (2013–14) and the Council of BME Chairs (2013–14). Previously, he served as also as the President of SFB (2003–04) and the Controlled Release Society (1987–88), and Chair of the AIMBE College of Fellows (2003–04) and the Council of BME Chairs (2012–13).  He is Associate Editor of the Biomedical Engineering Series of Books of Cambridge University Press, and the journals Biomedical Nanodevices, and Cell and Molecular Bioengineering. Nicholas Peppas is a Fellow of the American Chemical Society (ACS), American Physical Society (APS), Materials Research Society (MRS), AAAS, AIChE, BMES, AIMBE, SFB, CRS, American Association of Pharmaceutical Scientists (AAPS), the American Society for Engineering Education (ASEE) and an honorary members of the Italian Society of Natural Sciences. One of the most cited engineers in the world with 59,000 citations and H=120, he has published 1,300 papers and 55 patents and has authored or co–edited 37 books. More than 750 researchers have worked in his laboratories, including 100 postdoctoral fellows and 98 PhD students, 55 of them professors in other universities. Peppas holds a Dipl. Eng., National Technical University of Athens (1971), a Sc.D. from MIT (1973), honorary doctorates from the Universities of Ghent (Belgium), University of Parma (Italy), University of Ljubljana (Slovenia) and University of Athens (Greece), and an honorary professorship from Sichuan University, China.